Keppra And CBD Oil Interaction

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Hello! Advice needed ASAP! I'll give you a quick run down I am 24 years old and recently diagnosed with generalized epilepsy. Being diagnosed is literallu my biggest fear coming true ive always been afraid of having seziures and all these years ive had minor moments of blackkng out but never thought tbey were seziures until this year theyve gotten worse and my EEG showed Keppra And CBD Oil Interaction Pharmacokinetic and pharmacodynamic interactions occur with multiple ASMs. Pharmacokinetic interactions are frequently attributed to CYP2C19 and CYP3A4. Known

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Hello! Advice needed ASAP! I’ll give you a quick run down I am 24 years old and recently diagnosed with generalized epilepsy. Being diagnosed is literallu my biggest fear coming true ive always been afraid of having seziures and all these years ive had minor moments of blackkng out but never thought tbey were seziures until this year theyve gotten worse and my EEG showed seziure activity on both sides of my brain. My neuro prescribed me 500mg keppra (generic form) twice a day to start but I am so scared to start it due to everything I’ve read and heard about it and it’s side effects. I’ve done research on CBD and wanted to give it a try but I don’t know how effective it will be. I just want to do something that I know will work, also I had recently been trying to conceive and am worried what my new diagnoses means for TTC. Any advice on ether keppra or CBD would be great. Thanks in advance.

Comments

There is a host of
Submitted by epihelp on Tue, 2017-09-12 – 12:31

There is a host of information that is well known about Keppra and other seizure medications, but very little on cannabis or CBD. While a few research studies to date look positive for a pharmaceutical grade cannabadiol, we don’t know how it will work in all seizure types. Side effects can occur so it’s important to look into these. Talk to your health care team about options. What’s known about helpfulness, side effects and safety. There are concerns about safety of different products grown. Here is a section on cbd -http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy

There is a host of information that is well known about Keppra and other seizure medications, but very little on cannabis or CBD. While a few research studies to date look positive for a pharmaceutical grade cannabadiol, we don’t know how it will work in all seizure types. Side effects can occur so it’s important to look into these. Talk to your health care team about options. What’s known about helpfulness, side effects and safety. There are concerns about safety of different products grown. Here is a section on cbd -http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy

There is a host of information that is well known about Keppra and other seizure medications, but very little on cannabis or CBD. While a few research studies to date look positive for a pharmaceutical grade cannabadiol, we don’t know how it will work in all seizure types. Side effects can occur so it’s important to look into these. Talk to your health care team about options. What’s known about helpfulness, side effects and safety. There are concerns about safety of different products grown. Here is a section on cbd -http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy

I’m just nervous because I’ve
Submitted by Melissa1992 on Tue, 2017-09-12 – 18:03

I’m just nervous because I’ve never taken anything so serious and alot of people have said negative things about keppra and have told me to try CBD. I just don’t know which to do

I’m just nervous because I’ve never taken anything so serious and alot of people have said negative things about keppra and have told me to try CBD. I just don’t know which to do

I’m just nervous because I’ve never taken anything so serious and alot of people have said negative things about keppra and have told me to try CBD. I just don’t know which to do

Think a little. Do people
Submitted by just_joe on Sat, 2017-09-16 – 17:45

Think a little. Do people that have been prescribes and taking a medication go to a forum and talk about their medicatins if they are working? THe answer to my question is NO they are out with friends or with family and doing other things since the medications are working.Side effects do happen. They happen with any and all medications including over the counter meds. Aspirin has killed some people.I have been using keppra for about 15 years now and have had no problems with it. I have used about 20-23 other medications or couplings of medications. Keppra is th best medication I have used in the 50+ years I have been living and dealing with seizures. CBD is being researched. But just like medications it too has side effects.Recently diagnosed means you have researched forums and used the web to find out about side effects, Have you asked your neurologist about said side effects and how many patients he has had that got them? If not Why not talk to him? I know it sounds weird but I do believe I would take the medication since it was created to stop seizures. It was tested for years before ever going on market. Generally about 8% of the people taking the medications get a side effect. Which would equate to 92% not getting a side effect. I personal never thought about side effects since when I was diagnosed there were no computers. Research was done in real physical libraries. You listened and did what your doctors said to do. If you had an issue then is when you talked to your doctor. I did have an issue with the very first medication I was given. But it was not a side effect that cause my issue. It was the dosage was too high. I was taken off it and the next week was put on the same medication at a lower dosage and it worked well

Think a little. Do people that have been prescribes and taking a medication go to a forum and talk about their medicatins if they are working? THe answer to my question is NO they are out with friends or with family and doing other things since the medications are working.Side effects do happen. They happen with any and all medications including over the counter meds. Aspirin has killed some people.I have been using keppra for about 15 years now and have had no problems with it. I have used about 20-23 other medications or couplings of medications. Keppra is th best medication I have used in the 50+ years I have been living and dealing with seizures. CBD is being researched. But just like medications it too has side effects.Recently diagnosed means you have researched forums and used the web to find out about side effects, Have you asked your neurologist about said side effects and how many patients he has had that got them? If not Why not talk to him? I know it sounds weird but I do believe I would take the medication since it was created to stop seizures. It was tested for years before ever going on market. Generally about 8% of the people taking the medications get a side effect. Which would equate to 92% not getting a side effect. I personal never thought about side effects since when I was diagnosed there were no computers. Research was done in real physical libraries. You listened and did what your doctors said to do. If you had an issue then is when you talked to your doctor. I did have an issue with the very first medication I was given. But it was not a side effect that cause my issue. It was the dosage was too high. I was taken off it and the next week was put on the same medication at a lower dosage and it worked well

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Think a little. Do people that have been prescribes and taking a medication go to a forum and talk about their medicatins if they are working? THe answer to my question is NO they are out with friends or with family and doing other things since the medications are working.Side effects do happen. They happen with any and all medications including over the counter meds. Aspirin has killed some people.I have been using keppra for about 15 years now and have had no problems with it. I have used about 20-23 other medications or couplings of medications. Keppra is th best medication I have used in the 50+ years I have been living and dealing with seizures. CBD is being researched. But just like medications it too has side effects.Recently diagnosed means you have researched forums and used the web to find out about side effects, Have you asked your neurologist about said side effects and how many patients he has had that got them? If not Why not talk to him? I know it sounds weird but I do believe I would take the medication since it was created to stop seizures. It was tested for years before ever going on market. Generally about 8% of the people taking the medications get a side effect. Which would equate to 92% not getting a side effect. I personal never thought about side effects since when I was diagnosed there were no computers. Research was done in real physical libraries. You listened and did what your doctors said to do. If you had an issue then is when you talked to your doctor. I did have an issue with the very first medication I was given. But it was not a side effect that cause my issue. It was the dosage was too high. I was taken off it and the next week was put on the same medication at a lower dosage and it worked well

epilepsy community fears
Submitted by [email protected] on Sun, 2017-09-17 – 12:34

epilepsy community fears medical pot . keppra made my seizures worse, / six weeks in medical pot smoked daily is helping me . think for yourself

epilepsy community fears medical pot . keppra made my seizures worse, / six weeks in medical pot smoked daily is helping me . think for yourself

epilepsy community fears medical pot . keppra made my seizures worse, / six weeks in medical pot smoked daily is helping me . think for yourself

I believe we are in agreement
Submitted by epihelp on Sun, 2017-09-17 – 13:22

I believe we are in agreement for people to think about pros and cons. My point is to get the right information so people make informed decisions. There is quite a bit of research done on cannabis in scientific ways so we can learn more..

I believe we are in agreement for people to think about pros and cons. My point is to get the right information so people make informed decisions. There is quite a bit of research done on cannabis in scientific ways so we can learn more..

I believe we are in agreement for people to think about pros and cons. My point is to get the right information so people make informed decisions. There is quite a bit of research done on cannabis in scientific ways so we can learn more..

So you haven’t even tried it,
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:18

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it,
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:21

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

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So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

Just forget about meds. Your
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:20

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

So you haven’t even tried it,
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:22

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

Just forget about meds. Your
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:21

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

What state do you live in if
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:22

What state do you live in if I could ask?

Just forget about meds. Your
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:26

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

Just forget about meds. Your not the type of person to take them. Go to a doctor who will help you live your life WITH seizures. You might handle that better.

What state do you live in if
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:26

What state do you live in if I could ask?

You have to try Melissa then
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:26

You have to try Melissa then you’ll know.

So you haven’t even tried it,
Submitted by SeizingLisa on Mon, 2017-09-18 – 00:26

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

So you haven’t even tried it, is that what I read? It could be the one. Try it first at least if you have any side effects that will stop you from using it then stop it and call your Dr. Everyone reacts differently to meds. If you don’t at least try the meds the Dr. gives you then why are you going. Stop going to the Dr. Try some herbal remedies they might work for you. Good luck Melissa.

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Try the medication, because
Submitted by sindarintech on Mon, 2017-09-18 – 23:39

Try the medication, because it has a long documented history of helping people. Give it a couple of months for your body to adjust. Usually a good neuro will ease up your dosage over a period of time, so expect some periods where you just feel weird. Keep in mind that YOU are the final authority of what you put in your body. Different meds work different ways on different people. I got off the Keppra because it was making me too tired and groggy. That’s not an acceptable ‘remedy’. especially with so many other options, medication-wise. If Keppra doesn’t work for you, or has negative side-effects, insist on changing your medication. But give it sufficient time for your body to adjust first. CBD is still an unproven option and is not really something you want to try all by itself. There are also a lot of variations in production, which makes it difficult to gauge dose-wise. If you want to see if it helps, use it as a supplement to your primary medication. Be careful not to overthink things. you now know for sure that you have an epilepsy diagnosis, and can plan accordingly. It’s a treatable condition. I went for 20+ years not even knowing what was happening to me.

Try the medication, because it has a long documented history of helping people. Give it a couple of months for your body to adjust. Usually a good neuro will ease up your dosage over a period of time, so expect some periods where you just feel weird. Keep in mind that YOU are the final authority of what you put in your body. Different meds work different ways on different people. I got off the Keppra because it was making me too tired and groggy. That’s not an acceptable ‘remedy’. especially with so many other options, medication-wise. If Keppra doesn’t work for you, or has negative side-effects, insist on changing your medication. But give it sufficient time for your body to adjust first. CBD is still an unproven option and is not really something you want to try all by itself. There are also a lot of variations in production, which makes it difficult to gauge dose-wise. If you want to see if it helps, use it as a supplement to your primary medication. Be careful not to overthink things. you now know for sure that you have an epilepsy diagnosis, and can plan accordingly. It’s a treatable condition. I went for 20+ years not even knowing what was happening to me.

Try the medication, because it has a long documented history of helping people. Give it a couple of months for your body to adjust. Usually a good neuro will ease up your dosage over a period of time, so expect some periods where you just feel weird. Keep in mind that YOU are the final authority of what you put in your body. Different meds work different ways on different people. I got off the Keppra because it was making me too tired and groggy. That’s not an acceptable ‘remedy’. especially with so many other options, medication-wise. If Keppra doesn’t work for you, or has negative side-effects, insist on changing your medication. But give it sufficient time for your body to adjust first. CBD is still an unproven option and is not really something you want to try all by itself. There are also a lot of variations in production, which makes it difficult to gauge dose-wise. If you want to see if it helps, use it as a supplement to your primary medication. Be careful not to overthink things. you now know for sure that you have an epilepsy diagnosis, and can plan accordingly. It’s a treatable condition. I went for 20+ years not even knowing what was happening to me.

Why the hell are you getting
Submitted by Stephen L on Fri, 2017-09-22 – 17:28

Why the hell are you getting so defensive to her? Your passive aggressive tone isn’t needed nor wanted on a place like this. -_-

Why the hell are you getting so defensive to her? Your passive aggressive tone isn’t needed nor wanted on a place like this. -_-

Why the hell are you getting so defensive to her? Your passive aggressive tone isn’t needed nor wanted on a place like this. -_-

Keppra And CBD Oil Interaction

Pharmacokinetic and pharmacodynamic interactions occur with multiple ASMs.

Pharmacokinetic interactions are frequently attributed to CYP2C19 and CYP3A4.

Known interactions may not alter the ASM level outside the therapeutic range.

There is limited evidence currently for many ASMs.

There is limited evidence for the clinical relevance of many interactions.

Abstract

Objective

Cannabidiol is efficacious as an adjunctive treatment in children with epilepsy associated with Dravet and Lennox-Gastaut syndromes. As its role is currently adjunctive, we reviewed the interactions of cannabidiol with other antiseizure medications (ASMs).

Methods

A search of Cochrane, Pubmed and Embase databases from January 2015 to April 2020 was performed. All original research papers discussing interactions between cannabidiol and ASMs were included. Bibliographies of review articles were searched to identify further papers. Adverse events and side effects were excluded.

Results

Cannabidiol interacts with ASMs through both pharmacokinetic and pharmacodynamic mechanisms. Thirty studies were identified (eighteen observational cohort studies, two randomised-control trials, three case reports/series, three animal studies, two briefing reports, an analysis of cohort data and a clinical trial simulation). There is potential for pharmacokinetic interactions between CBD and brivaracetam, clobazam, eslicarbazepine, lacosamide, gabapentin, oxcarbazepine, phenobarbital, potassium bromide, pregabalin, rufinamide, sirolimus/everolimus, stiripentol, tiagabine, topiramate and zonisamide. Pharmacodynamic interactions were identified for clobazam, valproate and levetiracetam. An animal study identified that the brain concentration of ASMs may be altered while the serum concentration remains the same.

Conclusion

Pharmacokinetic and pharmacodynamic interactions exist between cannabidiol and ASMs. The cytochrome p450 system in particular has been implicated in pharmacokinetic interactions, although not exclusively. The existing literature is limited for some ASMs by studies having relatively small cohorts. As increasing numbers of patients use cannabidiol, specialists need to monitor closely for interactions clinically and with blood levels when required.

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