CBD Oil For Trigeminal Neuralgia


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Does the pain brought by trigeminal neuralgia bother you? Perhaps you want to consider using CBD oil to manage your symptoms and improve your quality of life. Trigeminal Neuralgia (TN) is a chronic pain condition that affects the trigeminal nerve, which carries sensation from your face to your brain.

Compare the Best CBD Oil for Trigeminal Neuralgia in 2022

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
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No other flavors

Approximately 300 drops total


Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
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No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients


The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
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Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test


Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
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Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team


cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
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60-Day Satisfaction Guarantee

Dropper is a bit shaky

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices


CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
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No other flavors

A bit pricey compared to competitors

Approximately 100 drops total


This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
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Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes


A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
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Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee


Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

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How CBD May Help With Trigeminal Neuralgia

TN ( trigeminal neuralgia ) is a medical condition characterized by chronic pain from the trigeminal nerve , which carries sensation from the face to the brain (1) .

CBD’s activity in the ECS ( endocannabinoid system ) may explain how this non-psychoactive compound may help with chronic pain and conditions like trigeminal neuralgia .

The ECS is vital to the CNS ( central nervous system ) and plays a role in regulating pain and inflammation (2) .

The ECS consists of cannabinoid receptors type 1 and 2 (CB1 and CB2), endocannabinoids, and enzymes.

Cannabinoids , like CBD and THC , may exert their antinociceptive properties through complex mechanisms involving effects on the CNS, spinal cord , and peripheral sensory nerves (3) .

Antinociceptive agents are compounds that can diminish pain without adverse effects on consciousness.

CB1 receptors play a key role in pain sensation (4) . Meanwhile, recent studies suggest that CB2 receptors may be involved in the antihyperalgesic activity of cannabinoids in acute, chronic, and neuropathic pain (5) .

Antihyperalgesic activity refers to the ability of certain compounds to counteract hyperalgesia or extreme sensitivity to pain.

Although CBD has a low binding affinity for both cannabinoid receptors , it may antagonize them in the presence of THC (6) .

The non-psychoactive compound may also regulate pain perception (7) . Thus, CBD may help with painful conditions such as trigeminal neuralgia .

Opioids are medications for persistent or severe pain. Despite their high potential for abuse, these prescription drugs are used mostly as an adjunct to anticonvulsants (8) .

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Opioids are also prevalent in patients with facial pain, including those who have TN (9 ) .

However, opioid abuse has become a national crisis in the United States, in which 90 Americans die by overdose each day (10) . For this reason, more studies are exploring the use of cannabis as a substitute for opioids (11 ) .

Cannabis refers to a group of plants, such as Cannabis sativa, Cannabis indica, and Cannabis ruderalis. These plants have more than 100 chemical components known as cannabinoids.

THC ( tetrahydrocannabinol ) and CBD ( cannabidiol ) are among the phytocannabinoids (plant-based cannabinoids) found in cannabis plants .

THC is the principal psychoactive compound of cannabis . The compound is responsible for the euphoric high users’ experience.

A study published in 2021 noted that, unlike opioids, cannabis has no reported deaths due to overdodse (12) .

Meanwhile, CBD is non-psychoactive. Some studies also suggest that CBD may antagonize at least some of the adverse effects of THC (13) .

The non-psychoactive compound has been of particular interest as a target for opioid use disorder (14) .

In a survey in California, about 80% of patients who used medical cannabis either as a substitute or in conjunction with opioid -based pain medication claimed that cannabis is more effective than opioids for pain (15) .

A study from the journal Neurology assessed the efficacy of medical cannabis in patients with trigeminal neuralgia ( 16) .

Of the 42 patients with TN, 81% reported improvements in their symptoms, while 50% said they reduced their opioid consumption with medical cannabis (17 ) .

The most efficacious dosage for the patients involved was a 1:1 ratio of THC to CBD (18) .

Although CBD may not be a standalone treatment for chronic pain , it is believed that using CBD as an adjunct therapy may provide pain relief , reduce the amount of opioid medication a patient is taking, and improve the overall quality of life (19) .

Benefits of Using CBD for Trigeminal Neuralgia

Cannabidiol has been shown to have anti-inflammatory and analgesic properties (20) . These potential health benefits may help individuals with trigeminal neuralgia .

TN is inflammation of the trigeminal nerve , a large three-part nerve in the head that provides sensation. It is a form of neuropathic pain associated with nerve lesions or nerve injuries.

It is believed that trigeminal nerve pain may be triggered by the contraction of blood vessels in the trigeminal nerve , damaging the trigeminal protective tissue (21) .

For individuals with TN, even mild stimulation of their faces, such as putting on makeup or brushing their teeth, may trigger an excruciating pain similar to an electric shock (22) .

A study from the European Journal of Pharmacology examined CBD’s efficacy in rat chronic inflammatory and neuropathic pain (23) .

The researchers administered 2.5-20 mg of CBD to neuropathic models and 20 mg of CBD to adjuvant-injected rats from days 7 to 14.

An adjuvant is an ingredient that may help create a more robust immune response in individuals receiving vaccines.

The findings indicated a potential for the therapeutic use of CBD in chronic painful states (24) .

It has been demonstrated that trigeminal neuralgia is common in patients with MS ( multiple sclerosis ), a disease that particularly affects the brain and spinal cord (25) .

Pain is a common symptom in multiple sclerosis , and about 75% of MS patients experience it (26) .

An elevated relative risk has also been associated with high blood pressure , particularly among women with trigeminal neuralgia (27) .

Preclinical studies showed that CBD may reduce blood pressure response to stress (28) .

These studies seem promising. However, they are either based on animal research or small clinical trials .

Still, the findings may be useful to researchers conducting further studies on CBD’s efficacy in painful conditions , like trigeminal neuralgia .

How to Take CBD for Trigeminal Neuralgia

Below are standard delivery methods by which CBD is taken into the body (29) :

  • Inhalation ( vape pens)
  • Ingestion ( edibles like gummies and capsules)
  • Sublingual or under the tongue ( tinctures , strips, tablets, and sprays)
  • Topical ( CBD creams , salves, lotions, and balms)

TN patients may initially experience mild attacks that can progress to more-frequent bouts of pain (30) .

Inhaling CBD using vape pens is the quickest way to benefit from the compound. CBD usually takes effect within two to 15 minutes via the inhalation route (31-32) . However, vaping may damage the lungs (33) .

Hence, talk with a healthcare professional experienced in cannabis use to determine which delivery route is best for trigeminal neuralgia or any health conditions .

CBD Dosage

The FDA ( Food and Drug Administration ) has not approved CBD as a treatment for trigeminal neuralgia . Hence, there is no standard CBD dosage for such a condition.

The general rule is to start with low doses . However, it is believed that mid-range doses between 10mg and 100mg of CBD daily may help with pain management (34) .

Still, it is best to talk with a healthcare professional with a background in cannabis use and dosing . They can advise you regarding the proper CBD dosage for trigeminal neuralgia .

How Long Does CBD Take to Help Trigeminal Neuralgia ?

How long it takes for cannabidiol to help with TN depends on several factors like the route of administration used, individual body weight, and CBD potency.

If you choose to take CBD via the inhalation route, expect to feel CBD’s effect within two to 15 minutes (35) . Meanwhile, when taken sublingually, the effects of CBD take much longer, usually between 15 and 30 minutes (36) .

How Long Will CBD Help With Trigeminal Neuralgia ?

How long CBD will last after it takes effect depends on its half-life and bioavailability.

Half-life is the time needed for the concentration of a specific substance to decrease by 50% of its starting dose in the body. It is believed that 94% to 97% of a drug will have been eliminated following four to five half-lives (37) .

The half-life of CBD was reported between 1.4 and 10.9 hours after oromucosal spray and 31 hours following smoking (38) .

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Meanwhile, bioavailability is the extent to which a particular drug becomes entirely available to its biological destination.

The bioavailability of CBD following smoking is 31% (39) . The bioavailability of cannabidiol when taken under the tongue is between 6% and 20% (40) .

Choosing the Best CBD Oil for Trigeminal Neuralgia

Most CBD companies are determined to provide high-quality CBD products like CBD oil for trigeminal neuralgia and overall wellness .

With many CBD brands promising the same thing, choosing the right product for you can be challenging.

Below are a few pertinent things to consider before buying any CBD product :

CBD Extracts

A full-spectrum CBD oil includes all the compounds of the cannabis plant , including CBD and other cannabinoids , essential oils, terpenes , and flavonoids.

A full-spectrum CBD provides the entourage effect, the theory wherein the biologically active compounds of cannabis work better together. Its THC concentration is also less than 0.3%.

Terpenes are aromatic compounds present in cannabis and many other plants. Flavonoids are plant chemicals with purported anti-inflammatory , antioxidant, and antiviral actions (41) .

A broad-spectrum CBD oil is almost the same as the full spectrum. However, it is nearly THC -free. Meanwhile, CBD isolates are made of pure CBD.


Check the ingredients to find out if there are any possible allergens or additives that may adversely affect you.

Generally, CBD products are infused with carrier oils, including MCT (medium-chain triglycerides) oil, coconut oil, and hempseed oil.

CBD Strength and Potency

The COA (certificate of analysis) is a document that indicates the amount of CBD, THC , and other ingredients in a CBD product .

The CBD company you choose must enlist the services of a third-party laboratory to check all products , ensuring objectivity and transparency.

Extraction Method

Carbon dioxide extraction , ethanol extraction , or solvent extraction with olive oil are preferred methods to create a safe CBD product (42) .

On the other hand, extraction techniques using hexane or butane may leave harmful residues.

Brand Reputation

Always purchase CBD products from a reputable store or dispensary authorized to sell CBD products .

Read customer feedback to get more insight about the manufacturer and its products.

The Potential Risks and Side Effects of Using CBD for Trigeminal Neuralgia

CBD is relatively safe and is well tolerated in humans and animals (43) . Still, the compound may induce risks and minor side effects , including (44) :

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue

The first-line treatment for trigeminal neuralgia is anticonvulsant medical therapy (45) . However, these drugs, primarily used to treat epileptic seizures, may interact with CBD (46) .

At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume (47) .

Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD (48) .

Legality of CBD

The 2018 Farm Bill indicates that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC on a dry weight basis are federally legal in the United States (49) .

In addition, some states like Colorado have passed laws allowing recreational and medical marijuana use. Still, these state laws do not change the fact that marijuana is listed as a Schedule I drug under federal law (50-51) .

Some states may even require a medical marijuana card to purchase cannabis products from authorized dispensaries . Therefore, make sure to research state legislations concerning cannabis use to avoid legal repercussions.

Product Frequently
Asked Questions

How can CBD help with trigeminal neuralgia?

There is no direct study suggesting that CBD can help with TN ( trigeminal neuralgia ).

However, CBD may be effective in different types of pain due to its analgesic properties (52) . The non-psychoactive compound may also help with several neurological disorders (53) .

TN is a rare neurological condition that causes chronic and severe facial pain (54) . A person with such a condition may feel burning sensations in the face.

As mentioned, CBD has pain-relieving effects (55) . These properties may help with painful conditions like trigeminal neuralgia .

What evidence or research exists to say that CBD helps with trigeminal neuralgia?

A 2019 study suggested that medical cannabis may be a valuable part of a comprehensive pain management plan for TN patients (56) . Researchers reported that the 1:1 ratio of THC to CBD is the most effective dosage among these patients.

Although CBD may not be a standalone treatment for chronic pain caused by various medical conditions like TN, the compound may provide pain relief to people and therefore contribute to their improved quality of life (57) .

Is there any evidence that CBD can make trigeminal neuralgia worse?

No evidence suggests that CBD can make trigeminal neuralgia worse. However, CBD may still induce risks and side effects like fatigue (58) .

Will CBD interact with any current medication I may be taking for trigeminal neuralgia?

CBD may interact with other medications like anticonvulsants , which are first-line treatments for TN (59-60) .

At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume (61) .

Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD (62) .

Are there other treatments I should consider alongside CBD to help with trigeminal neuralgia?

Painkillers like paracetamol are ineffective in managing pain associated with TN. One type of pain relief medication prescribed to TN patients is an anticonvulsant (63) .

Muscle-relaxing agents may also be used to help with TN. However, their side effects include drowsiness, confusion, and nausea (64) .

Thus, ensure to talk with your doctor if you consider other treatments alongside CBD to help manage TN symptoms.

Can I fail a drug test if I use CBD for trigeminal neuralgia?

CBD does not cause euphoria (65) . Still, some CBD products have small amounts of THC that may build up in the body when taken regularly in a span of four to six days (66) .

An increased THC level in the bloodstream may result in a positive drug test.

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What is the dosage for trigeminal neuralgia?

There is no standard CBD dosage for TN. However, doses between 10mg and 100mg may help with pain management (67) . TN is characterized by chronic pain (68) .

How should I use CBD oil for trigeminal neuralgia?

Inhaling CBD using vape pens usually takes effect within 2 to 15 minutes via the inhalation route (69) . However, extra caution is needed as vaping may damage the lungs (70) .

Trigeminal neuralgia: How cannabis can help with the excruciating pain

Although it is rare, approximately 1 in 10,000 people develop this condition each year.

The main symptom of trigeminal neuralgia is a sudden attack of severe, sharp, shooting facial pain. The pain may last only a few seconds to a few minutes, but can occur repeatedly, during an attack. The pain is often described as excruciating, like an electric shock. The attacks can be so severe that you’re unable to move while they’re happening. Pain can also arise in other areas that are supplied by the trigeminal nerve, such as the cheek, jaw, eye and forehead.

Initially, it can present itself as short, slight pain, but TN can develop and have more enduring impacts, which can take the form of longer-lasting, more intense pain. The condition affects more women than men and is more likely to affect people who are over 50.

Helen, a patient at Integro Medical Cannabis Clinics, recounts her story from first using conventional medicines to receiving her medical cannabis prescription. Since then, she has seen a significant improvement in her quality of life.

At Integro Clinics, our doctors have seen the positive benefits that cannabis medicines can have in managing our patient’s symptoms of trigeminal neuralgia.

Trigeminal Neuralgia: Helen’s Story

Helen began to suffer from TN 15 years ago, which has meant that she has been unable to work since completing her master’s degree at university. Chronic back pain, which then spread up to her neck, triggered Helen’s TN, which began with agonising migraines.

Helen describes her pain as always starting on the left side of her face.

“Trigeminal neuralgia comes as a permanent headache around my left eye, it feels like I actually have pain in my eye. The pain spreads into my forehead and my jaw as well. It is a constant, mild pain, but if my neck gets stiff, or if I get stressed, it becomes a more severe pain. My TN means I’m light sensitive and I can only use the computer for short periods at a time. If I am looking at the screen for too long, my headaches get worse, and then as a result the pain in my face flares up.” – Helen

Helen was prescribed anticonvulsants by her doctor, such as pregabalin. She did not find that they eased the pain and they caused short term memory loss.

She added: “When I came off the pregabalin tablets, I realised that they had not actually helped me. I was still feeling the same pain as when I was on the medicine. The only thing that changed was that my short term memory started to get better.”

Helen wanted to find an alternative way to manage her pain but did not want to suffer the side effects of using conventional medicines again. After searching through Facebook pages on TN, Helen found out that medical cannabis was legal and available on prescription and could actually help her without any horrible side effects.

“I eventually discovered that cannabis clinics existed on Facebook. I started as a patient at one clinic, but I soon realised that the oil they prescribed wasn’t working for me. So, I then became a patient at Integro and this is where I started to see the benefits of medical cannabis. The team at Integro really helped me to find the best combination of THC and CBD that works for me. I felt like I was listened to and they wanted to help me, rather than just seeing me as being a fussy patient.

The CBMP’s that I’m taking now has made a huge difference in my life. They relax the muscles in my neck which means that my TN is triggered far less than before. I also get a better night’s sleep which in turn reduces the symptoms of my TN. Even though the pain is still there, it’s much less severe, I can actually read a book or look at my computer screen for longer than I could before. Cannabis has really given me my life back.” – Helen

Chornic pain and cannabis

Dr Anthony Ordman, Senior Consultant at Integro Medical Clinics, has seen how cannabis medicines can help patients suffering from TN. The cannabis helps them to manage their symptoms and relieve their pain so they can get on with activities such as reading, or working on a computer screen

“In trigeminal neuralgia, nerve cells fire off in an uncontrolled way which sends pain signals to the brain, experienced as severe pain in the face and mouth.

“Only one conventional medicine will help, carbamazepine, which doesn’t always help completely. Cannabis medicines help to settle down the over-excited nerves and to dampen down their excessive firing. But then it also helps with the secondary effects of TN such as muscle tension, low mood, poor sleep and so on.”

He added: “At Integro Clinics, we aim to never cause any adverse effects or dependency, but the same can’t be said for conventional medicines. Integro Medical Clinics Ltd always recommends remaining under the care and treatment of your GP and specialist for your condition, while using cannabis-based medicines, and the Integro clinical team would always prefer to work in collaboration with them.”

If you would like further information or to speak to Dr Anthony Ordman please contact Integro Clinics:

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